FC Barcelona 4-0 VfB Stuttgart (agg: 5-1) Lionel Messi scored two and set up another as the holders progressed after inflicting a record-equalling European defeat on Stuttgart.
FC Girondins de Bordeaux 2-1 Olympiacos FC (agg: 3-1) Goals from Yoann Gourcuff and Marouane Chamakh eased Bordeaux's nerves and earned a first quarter-final since 1988.
Lionel Messi has collected a €100,000 cheque from UEFA before FC Barcelona's game against VfB Stuttgart, which will then be donated to the International Committee of the Red Cross.
Chelsea FC 0-1 FC Internazionale Milano (agg: 1-3) José Mourinho enjoyed a happy return to Stamford Bridge as Samuel Eto'o's late goal confirmed the visitors' place in the last eight.
Sevilla FC 1-2 PFC CSKA Moskva (agg: 2-3) Keisuke Honda set up one and scored the winner as the Russian side reached the quarter-finals for the first time.
As Manuel Jiménez reflected on missed chances and a "disastrous" defeat for Sevilla FC, PFC CSKA Moskva boss Leonid Slutsky was typically composed despite securing a historic first.
José Mourinho was in ebullient mood after the defeat of his former employers Chelsea FC took FC Internazionale Milano into the quarter-finals in impressive fashion.